If you’re looking for the best adsense placement tips you need to take into account the the Google Panda algorithm change which first went into effect in February 2011.
While it’s not spelled out obviously that ad-to-content ratio can be a problem, keep in mind that the Google Panda / Farmer update was designed to combat content farms – which in most cases make money with Adsense.
If you look more closely, you can find this question among many others that are behind the Panda algorithm:
Does this article have an excessive amount of ads that distract from or interfere with the main content?
Vanessa Fox also mentions ad-to-content ratio as one of likely factors behind the Farmer update.
But what’s really interesting is that Google Adsense has changed their best adsense placement tips – but unfortunately I think it’s not that well publicized.
The suggested adsense placement / layout is now like this:
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