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The Georgia Institute of Technology and Micron Biomedical have been awarded $2.5 million in grants from the Bill & Melinda Gates Foundation to advance the development of dissolvable microneedle patches for polio immunization. The patches will be studied to evaluate their potential role as part of the worldwide efforts to eradicate polio. 
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Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node. Masahiro Kitano et al (2016), Proceedings of the National Academy of ...
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Taken together, these data show auto-antigenic peptide delivery into skin using coated MNs results in prolonged retention and enhanced antigen presentation compared to conventional ID delivery and this approach may have potential in individuals identified as being at a high risk of developing type 1 diabetes and other autoimmune diseases.
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Please visit us at http://clinicalresolution.com for any questions about microneedling and skincare products. This video covers the mechanics of the InnoPen ...
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The aim of this project was to study the influence of microneedles on transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride across porcine ear skin in vitro. Microchannel visualization studies were carried out and characterization of the microchannel depth was performed using confocal laser scanning microscopy (CLSM) to demonstrate microchannel formation following microneedle roller application.
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This review explores the feasibility of innovative MNs used as a drug delivery carrier. Because most of the SMNs and HMNs have many limitations, it is difficult to achieve therapeutic efficacy. Therefore, many scientists are investigating functional modifications of MNs through covalent and non-covalent methods, especially for CMNs and DMNs. The biomedical applications of MNs are growing and new exciting improvements could be achieved, thus resulting in better micro/nano technologies in the near future.
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Researchers at MIT are developing a method of delivering vaccines with patches of tiny needles that would embed a substance containing the vaccine onto the skin, much like a tattoo. The technique would eliminate the need of a syringe. The microneedles would measure 250 microns wide by 650 microns long, and would be coated with a biodegradable film comprised of layers of polymers containing the vaccine. The patch of microneedles would penetrate the skin less than a millimeter (650 microns) deep, enough to deliver the vaccine, but not deep enough to affect blood vessels and nerve endings to cause pain. The patch would embed the film into the skin. The film would gradually wear away over a sustained period of time, gradually releasing the vaccine into the skin.
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Join us and Donate Today to Help Make the Life of a Child Living with Diabetes a Little Less Painful.
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Researchers in the United States (US) have developed 3D printed micro-needles, which will be able to administer the medicinal drugs in the human body without any pain to the patient.
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For years, we’ve been told to break habits that hurt our skin (i.e. don’t pick at scabs) but could we be doing it wrong? Could hurting our skin actually make it look better? Many plastic surgeons and dermatologists say yes.
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Eli Lilly ($LLY) is upsizing its New York City R&D outpost, planning to add 50 new jobs and take up more lab space with a particular focus on immuno-oncology.
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Team Leuko, an international group collaborating between the Massachusetts Institute of Technology (MIT) and a handful of centers, hospitals, and foundations primarily located in Madrid, Spain, has developed a device that counts patients’ white blood cells in real-time through the skin (i.e., without drawing blood). With the use of this device, patients undergoing chemotherapy will be able to track their immune behavior responsively, much as diabetics can quickly gauge and react to their blood glucose levels. Via Beeyond
Yotam Levin's insight:
Sounds amazing. i wonder if they could differentiate leuko from lymphocytes, in which case this has far greater applicability.. But even so, this could be the equivalent of oximetry to CBC (at least WBC)
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Dick Crawford, an engineer and entrepreneur who is chair, co-founder and CEO of PKA SoftTouch Corp. in Lakefield says his development team has been working on the microneedle for nine years.
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Meant to accelerate the potential of immunotherapy in treating cancer, The National Immunotherapy Coalition has just been launched by leaders from Amgen, Celgene, GlaxoSmithKline, Merck, and NantWorks – along with Independence Blue Cross and many others. Here’s why:
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The purpose of this study was to evaluate the characteristics of exendin-4 tip-loaded microneedle arrays and to compare their acute efficacy with subcutaneous injections in type 2 diabetic GK/Slc rats.
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Fresh Prince of bioMEMs rap Microneedle fabrication and targeted drug delivery mechanisms
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This video covers the mechanics of the InnoPen Microneedling device and is intended for Medical Providers and Aesthetic Professionals.
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The results illustrate that this microneedle delivery system is effective in delivering collagen I into the epidermis and dermis of porcine and human skin. Since the technique presented in this paper is quick, safe, effective and easy, it can be considered as a new collagen delivery method for cosmetic and therapeutic applications.
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Our pioneering oncology research and development could potentially transform the way cancer is treated. See how AbbVie teams are working together to take on the challenges of cancer.
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In recent years there has been a growing concern regarding needle-based drug delivery devices due to needle phobia, increasing cases of needlestick injuries and the transmission of blood-borne diseases. Needle-free drug delivery devices are considered as an effective alternative and novel technique to introduce drugs into a patient's body without invading the skin with a needle. It is growing in popularity and has received considerable attention during the past few years primarily due to painless, effective and safe drug delivery methods. Needle-free drug delivery devices typically include needle-free injectors, inhalers, transdermal patches and other devices based on novel needle technologies (e.g., microneedles and advanced pen needles).
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Carl Schoellhammer, winner of the 2015 Lemelson-MIT National Collegiate Student prize in the "Cure it!" graduate category is developing two inventions that will drastically enhance pain-free drug delivery in patients via the gastrointestinal (GI) tract. His first invention, the Microneedle Pill (mPill), allows medicine that is traditionally administered by painful injection to be ingested orally. The ingestible capsule has small micron-scale needles protruding from it, which introduce the drug directly into the GI tissue in a painless and safe manner. His second invention, the Ultrasound Probe (uProbe), enables the fast, local delivery of therapeutics to the GI tract by using low frequency ultrasound to physically drive medication into tissue painlessly.
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Take a look at this video about infini - microneedles with radiofrequency for wrinkles by Dr. John J. Martin, Jr.
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Chinese cancer immunotherapy player BeiGene just filed a $100 IPO with the U.S. Securities Exchange Commission to advance its clinical pipeline of BTK, RAF and PARP inhibitors.
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Photodynamic therapy involves delivery of a photosensitising drug that is activated by light of a specific wavelength, resulting in generation of highly reactive radicals. This activated species can cause destruction of targeted cells. Application of this process for treatment of microbial infections has been termed "photodynamic antimicrobial chemotherapy" (PACT).
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Scientists from the University of Akron and University of Texas today announced a pioneering technique for producing 3D micro-printed needles. The needles, measuring no more than 1 mm high, are made from a biomaterial that after painlessly delivering the drug would simply degrade into the patient’s body. They could be used to treat a wide range of diseases including skin cancer and help reduce the stigma associated with injections.
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